Flavonoids Isolated from Heat‐Processed <i>Epimedium koreanum</i> and Their Anti‐HIV‐1 Activities

Abstract

Abstract Systematic phytochemical investigation on heat‐processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl‐flavonol glycosides, koreanosides A–E ( 1 – 5 , resp.). Their structures were elucidated on the basis of detailed analysis of the 1D‐ and 2D‐NMR spectroscopic data and chemical reactions. Apigenin ( 11 ) exhibited moderate anti‐HIV‐1 activity with an EC 50 value of 12.8±3.27 μg/ml.