Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells

Abstract

TGF-β-mediated phosphorylation of individual serine/threonine sites in the linker region of Smad2 occurs in a highly specific manner by kinases. These phosphorylations provide an opportunity to further understand a therapeutically targeted and very specific signalling pathway in vascular endothelial cells.