Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt‐dependent mechanisms

Abstract

Resveratrol delayed the onset of EPC senescence and this effect was accompanied by activation of telomerase through the PI3K-Akt signalling pathway. The inhibition of EPCs senescence by resveratrol might protect EPCs against dysfunction induced by pathological factors in vivo and improve EPC functional activities in a way that may be important for cell therapy.