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Relationship between Proliferative and Effector Phases of the Mixed Lymphocyte Reaction and Graft-Vs-Host Reaction
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1973
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Lymphocyte DevelopmentImmunologyImmunologic MechanismAntigen ProcessingImmunotherapyAbstract SpleenMixed Lymphocyte ReactionLymphatic SystemBalb MiceCell TransplantationTransplantationAutoimmune DiseaseAllergyGraft-vs-host ReactionAutoimmunityCell BiologyCellular Immune ResponseMedicineEffector PhasesGraft RejectionThymus Cells
Abstract Spleen and thymus cells from BALB mice were shown to undergo proliferation in the mixed lymphocyte reaction and graft-vs-host reaction in response to antigens of H-2 identical DBA mice without generating effector lymphocytes exhibiting specific cytotoxicity for DBA target cells. Both proliferation and generation of cytotoxicity occurred when BALB lymphocytes were exposed to antigens of H-2 non-identical CBA mice. The proliferative response of BALB thymocytes to CBA antigens greatly exceeded that of BALB spleen cells, even though the generation of cytotoxic lymphocytes was greater in the spleen population. These data suggest that the proliferative and effector phases of the mixed lymphocyte reaction and the graft-vs-host reaction may be mediated by separate lymphoid cell populations having differing antigen requirements for activation.