Role of polymorphic <i>N‐acetyl transferase2</i> and <i>cytochrome P4502E1</i> gene in antituberculosis treatment‐induced hepatitis

Abstract

The study demonstrates for the first time a possible association between the DraI polymorphism of the CYP2E1 gene and the risk of ATT hepatotoxicity. The genotyping of the NAT2 and CYP2E1 genes could possibly identify the groups at highest risk of developing ATT-induced hepatitis prior to medication.