Concepedia

Use of Constitutive G Protein-Coupled Receptor Activity for Drug Discovery

Grace Chen, James M. Way, Susan Armour, Chris Watson, Ken Queen, Channa Jayawickreme, Wen Ji Chen, Terry Kenakin

Molecular Pharmacology · 2000 · 110 citations · 24 references

DOI

Concepts

References

24

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

, , +17

Pharmacologic Analysis of Drug Receptor Interaction

Kenakin. T. Kenakin · Therapeutic Drug Monitoring · 1988 · 930 citations

, , +17

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Tommaso Costa, A. Herz · Proceedings of the National Academy of Sciences · 1989 · 530 citations · Full text

, , +15

A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1

Monsif Bouaboula, Sylvie Perrachon, Laura Milligan et al. · Journal of Biological Chemistry · 1997 · 463 citations · Full text

, , +14

Basic methods in molecular biology

Christopher J. Howe · Trends in Genetics · 1987 · 436 citations

, , +13