Concepedia

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Jean‐Nicolas Dumez, Jonas Milani, Basile Vuichoud, Aurélien Bornet, Julie Lalande-Martin, Illa Téa, Maxime Yon, Mickaël Maucourt, Catherine Deborde, Annick Moing,

The Analyst · 2015 · 108 citations · 24 references

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Abstract

Natural abundance (13)C NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.

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