Concepedia

Chemically Modified Oligonucleotides Exhibit Decreased Immune Stimulation in Mice

Scott P. Henry, Kim Stecker, Doug A. Brooks, David Monteith, Boyd Conklin, C. Frank Bennett

Journal of Pharmacology and Experimental Therapeutics · 2000 · 146 citations · 29 references

DOI

Concepts

References

29

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Dennis M. Klinman, Ae‐Kyung Yi, Serge L. Beaucage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations

, , +17

Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

Brett P. Monia, Elena A. Lesnik, C. Gonzalez et al. · Journal of Biological Chemistry · 1993 · 770 citations · Full text

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Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

Serge L. Beaucage, Radhakrishman P. Iyer · Tetrahedron · 1992 · 708 citations

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2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

Brenda F. Baker, Sidney S. Lot, Thomas P. Condon et al. · Journal of Biological Chemistry · 1997 · 377 citations · Full text

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