Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients

Abstract

The pharmacokinetics of clomethiazole were characterized in acute stroke patients and the analysis excluded several possible covariates of interest in drug development. The time course of sedation could be quantitatively described during the first 24 h following an acute stroke in the presence or absence of clomethiazole treatment.