Concepedia

The prognostic and predictive value of <i>KRAS</i> oncogene substitutions in lung adenocarcinoma

Liza C. Villaruz, Mark A. Socinski, Diana E. Cunningham, Simion I. Chiosea, Timothy F. Burns, Jill M. Siegfried

Cancer · 2013 · 52 citations · 18 references

DOIFull text

Open access

Abstract

KRAS codon 13 mutations and MASI were identified as candidate biomarkers for prognosis, and it may be useful to incorporate them into prospective studies evaluating novel therapies in KRAS-mutant lung adenocarcinoma.

References

18

Somatic mutations affect key pathways in lung adenocarcinoma

Li Ding, Gad Getz, David A. Wheeler et al. · Nature · 2008 · 2.7K citations · Full text

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Characterizing the cancer genome in lung adenocarcinoma

Barbara A. Weir, Michele Sue‐Ann Woo, Gad Getz et al. · Nature · 2007 · 1.1K citations · Full text

A new genetic concept: Uniparental disomy and its potential effect, isodisomy

Eric Engel · American Journal of Medical Genetics · 1980 · 568 citations

, , +29

Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome

Nathan T. Ihle, Lauren A. Byers, Edward S. Kim et al. · JNCI Journal of the National Cancer Institute · 2012 · 523 citations · Full text

Association of <i>KRAS</i> G13D Tumor Mutations With Outcome in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy With or Without Cetuximab

Sabine Tejpar, Ilhan Celik, Michael Schlichting et al. · Journal of Clinical Oncology · 2012 · 352 citations