Crystal structure of a suicidal DNA repair protein: the Ada O6‐methylguanine‐DNA methyltransferase from E. coli.

Improved methods for building protein models in electron density maps and the location of errors in these models

T. Alwyn Jones, Jin-yu Zou, Sandra W. Cowan et al. · Acta Crystallographica Section A Foundations of Crystallography · 1991 · 12.7K citations

Life Sciences, Biochemistry, Biomolecular Modeling +16

Crystallographic <i>R</i> Factor Refinement by Molecular Dynamics

Axel T. Brünger, John Kuriyan, Martin Karplus · Science · 1987 · 2K citations

Natural Sciences, Biophysics, Chemistry +17

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

D. M. Blow, Jens J. Birktoft, B. S. Hartley · Nature · 1969 · 1.1K citations

Life Sciences, Biochemistry, Molecular Biology +3

Genetic studies of the lac repressor

Christine Coulondre, Jeffrey H Miller · Journal of Molecular Biology · 1977 · 605 citations

Life Sciences, Genetics, Molecular Biology +3

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

Wei Yang, Wayne A. Hendrickson, Robert J. Crouch et al. · Science · 1990 · 475 citations

Life Sciences, Biochemistry, Molecular Biology +17