<i>In vitro</i> and <i>in vivo</i> antitumoral action of metformin on hepatocellular carcinoma

Abstract

Our findings indicate that metformin is effective at initiating apoptosis and inhibiting key survival signaling pathways in HCC cells. These data provide a foundation for further studies to evaluate metformin in the clinic either as a single agent or in combination with other first-line agents as a treatment option for HCC.