Cytotoxic metabolites from the endophytic fungus Penicillium chermesinum: discovery of a cysteine-targeted Michael acceptor as a pharmacophore for fragment-based drug discovery, bioconjugation and click reactions

Abstract

A novel tetracyclic polyketide uniquely spiro-attached with a γ-lactone ring and a potent cytotoxic agent possessing a thiol-reactive pharmacophore were isolated from the mangrove endophytic fungus<italic>Penicillium chermesinum</italic>.