Concepedia

Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis

Jerzy Świerkot, Ryszard Ślężak, Paweł Karpiński, Justyna Pawłowska, Leszek Noga, Jacek Szechiński, Piotr Wiland

Polskie Archiwum Medycyny Wewnętrznej · 2015 · 40 citations · 18 references

DOIFull text

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Abstract

The MTHFR 677CC and GGH 401TT and CT genotypes were associated with a reduction in the number of MTX-related adverse events. Future allele and genotype analyses may help identify the subsets of RA patients with an increased risk of adverse effects.

References

18

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single‐nucleotide polymorphisms in genes coding for folate pathway enzymes

Judith A.M. Wessels, Jeska K de Vries‐Bouwstra, B.T. Heijmans et al. · Arthritis & Rheumatism · 2006 · 206 citations

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis

Thierry Dervieux, Neal S. Greenstein, Joel M. Kremer · Arthritis & Rheumatism · 2006 · 199 citations

The C677T mutation in the methylenetetrahydrofolate reductase gene: A genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients

Annelies E. van Ede, Roland Laan, Henk J. Blom et al. · Arthritis & Rheumatism · 2001 · 195 citations

Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study

Thierry Dervieux · Annals of the Rheumatic Diseases · 2005 · 175 citations · Full text

Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene

Yackov Berkun · Annals of the Rheumatic Diseases · 2004 · 171 citations · Full text