Journal of Bacteriology · 1988 · 55 citations · 17 references
Life SciencesGeneticsMolecular BiologyEnzymologyGene RegulationMicrobial GeneticsBacterial Gene RegulationGene Regulation In MicrobesPathway RegulationStress ToleranceStress-responsive Gene RegulationTranscriptional Regulation In ProkaryotesEscherichia ColiFeedback InhibitionOsmotic StressOsmotic Stress AdaptationOsmotic Stress ResponseOsmotic Stress ToleranceProline BiosynthesisStress-induced Gene Regulation
A single base pair change has been found in a site corresponding to a regulatory region of the first enzyme in the proline biosynthetic pathway. This change alters feedback inhibition and is responsible for the synthesis of high levels of proline that enable Escherichia coli to withstand osmotic stress.
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