Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

Adam Siddiqui-Jain, Denis Drygin, Nicole Streiner et al. · Cancer Research · 2010 · 513 citations

Medicine, Oncology, Pharmacology +16

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

Karsten Niefind, Bárbara Guerra, Inessa Ermakowa et al. · The EMBO Journal · 2001 · 445 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

The selectivity of inhibitors of protein kinase CK2: an update

Mario A. Pagano, Jenny Bain, Zygmunt Kazimierczuk et al. · Biochemical Journal · 2008 · 242 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Casein kinase II is elevated in solid human tumours and rapidly proliferating non‐neoplastic tissue

Ursula Münstermann, Gerhard Fritz, Gerhard Seitz et al. · European Journal of Biochemistry · 1990 · 219 citations · Full text

Medicine, Oncology, Pathology +15