Movement Disorders · 2009 · 24 citations · 14 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsMedical GeneticsMovement DisordersDisease Susceptibility LociGenetic DisordersGenotype-phenotype Association AnalysisMovement Disorder GeneticsParkinson DiseaseParkinsonian DisordersCommon Genetic VariantsDisease RiskGenetic Risk VariantsGenotype-phenotype AssociationsHaplotype Frequency AnalysisNeurodegenerative GeneticsParkinson's Disease GeneticsSporadic Neurodegenerative Disease Susceptibility
Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.
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The International HapMap Project
Richard A. Gibbs, John W. Belmont, Paul Hardenbol et al. · Nature · 2003 · 6.2K citations · Full text
Efficiency and power in genetic association studies
Paul I. W. de Bakker, Roman Yelensky, Itsik Pe’er et al. · Nature Genetics · 2005 · 1.7K citations