Concepedia

Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity

Tobias Klein, Nicole Heinzel, Paul Kröll, Matthias Brunner, Christoph Herwig, Lukas Neutsch

Journal of Biotechnology · 2015 · 25 citations · 29 references

DOI

Concepts

References

29

Recombinant protein therapeutics from CHO cells : 20 years and counting

Karthik P. Jayapal, Katie F. Wlaschin, Wei Hu et al. · Chemical engineering progress · 2007 · 479 citations

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A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH

William M. Miller, Harvey W. Blanch, C. R. Wilke · Biotechnology and Bioengineering · 1988 · 474 citations

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Lactate dehydrogenase (LDH) activity of the number of dead cells in the medium of cultured eukaryotic cells as marker

Cathérine Legrand, J. M. Bour, Claire Jacob et al. · Journal of Biotechnology · 1992 · 400 citations

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Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

Andrew J. Dorner, L C Wasley, Randal J. Kaufman · The EMBO Journal · 1992 · 345 citations · Full text

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Metabolic flux analysis of hybridoma cells in different culture media using mass balances

Hendrik P. J. Bonarius, Vassily Hatzimanikatis, K.P.H. Meesters et al. · Biotechnology and Bioengineering · 1996 · 262 citations · Full text

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