Translating research evidence into clinical practice: new challenges for critical care

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

New England Journal of Medicine · 2000 · 12.7K citations · Full text

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation

John P. Kress, Anne S. Pohlman, Michael O’Connor et al. · New England Journal of Medicine · 2000 · 2.9K citations · Full text

Does More Intensive Treatment of Acute Myocardial Infarction in the Elderly Reduce Mortality?

Mark McClellan · JAMA · 1994 · 771 citations

Cost Effectiveness of Thrombolytic Therapy with Tissue Plasminogen Activator as Compared with Streptokinase for Acute Myocardial Infarction

Daniel B. Mark, Mark A. Hlatky, Robert M. Califf et al. · New England Journal of Medicine · 1995 · 523 citations · Full text