Studies on ‘orotic acid fatty liver’

Abstract

The development of fatty liver on feeding orotic acid to weanling rats was first reported by Stan- derfer & Handler (1955). The increase in fat was found to be entirely in the neutral-lipid fraction. An increase in liver cholesterol in addition to the neutral-lipid fraction in the rats fed with orotic acid has been observed in our laboratory in pre- liminary experiments by D. S.