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Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

Cdc2 Protein KinaseChromatinGenome InstabilityNuclear Dna-binding ProteinCell RegulationCell DivisionNatural SciencesMolecular BiologyDna ReplicationNuclear OrganizationCell CycleMedicineCell Biology