Concepedia

Exosomal Doxorubicin Reduces the Cardiac Toxicity of Doxorubicin

Giuseppe Toffoli, Mohamad Hadla, Giuseppe Corona, Isabella Caligiuri, Stefano Palazzolo, Sabrina Semeraro, Amelia Gamini, Vincenzo Canzonieri, Flavio Rizzolio

Nanomedicine · 2015 · 146 citations · 31 references

DOIFull text

Open access

Abstract

We demonstrated that exoDOX was less toxic than DOX through its altered biodistribution.

References

31

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez‐Erviti, Yiqi Seow, HaiFang Yin et al. · Nature Biotechnology · 2011 · 4.7K citations

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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Héctor Peinado, Maša Alečković, Simon Lavotshkin et al. · Nature Medicine · 2012 · 3.6K citations · Full text

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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Yanhua Tian, Suping Li, Jian Song et al. · Biomaterials · 2013 · 1.7K citations

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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

Isabella Parolini, Cristina Federici, Carla Raggi et al. · Journal of Biological Chemistry · 2009 · 1.5K citations · Full text