Fibrillar Bundles in the Nucleus of Blood Lymphocytes from Leukemic and Nonleukemic Patients

Abstract

Abstract Fibrillar bundles were found in the nuclei of blood lymphocytes from 15 of 30 normal individuals. Similar fibrils were found in three of 16 cases of chronic lymphocytic leukemia, and in one of eight cases of Hodgkin’s disease. Nuclear bundles when observed in a sample were found only in small numbers. No points of continuity between the nuclear and the cytoplasmic fibrils could be found.