Concepedia

Publication | Closed Access

Genetic barriers for integrase inhibitor drug resistance in HIV type-1 B and CRF02_AG subtypes.

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Citations

0

References

2009

Year

Isabelle Malet, Cathia Soulié, Anne Derache, Koita, Bahia Amellal, Luba Tchertanov, Olivier Delelis, Laurence Morand‐Joubert, Robert L. Murphy, Mamadou Cissé,
PubMed

Abstract

The major IN mutations E92Q, Q148K/R/H, N155H and E157Q (implicated in the resistance of IN inhibitors RAL and EVG) are highly conserved between subtypes B and CRF02_AG and display a similar genetic barrier. However, subtype CRFO2_AG showed a higher genetic barrier to acquire mutations 6140S, 6140C and V1511 as compared with subtype B, which could play a role in the resistance to RAL and/or EV6.