PubMed · 1979 · 213 citations · 11 references
MedicineOncologyPathologyMetastasisSurgical PathologyTumor PathologyMalignant NeoplasmsMalignant TumorsTumor MorphologyUterine FibroidsUterine LeiomyomaVulvar CancerLeiomyosarcoma TherapyMarginsMitotic Activity AssessmentMitotic FiguresSmooth Muscle Histology
The study examined 32 vulvar smooth muscle tumors to identify pathological features that distinguish leiomyomas from leiomyosarcomas and to guide treatment decisions. The authors retrospectively reviewed 32 vulvar smooth muscle tumors, collecting clinical and histopathologic data with follow‑up ranging from 16 months to 20 years (median 9 years). No metastases occurred; recurrence was limited to four tumors, with aggressive behavior seen only in infiltrating lesions with high mitotic counts, while pregnancy‑associated tumors showed myxoid change but remained benign.
The clinical and pathologic features of 32 smooth muscle tumors of the vulva were studied to determine the pathologic characteristics that best relate to the clinical behavior and to define criteria for separating leiomyomas from leiomyosarcomas. The length of follow-up ranged from 16 months to 20 years, with a median of 9 years. None of the tumors metastasized. Of the 4 neoplasms that recurred, the 2 with infiltrating margins recurred within 1 year and of these 2, the one with more than 5 mitotic figures in 10 high-power fields (HPF) recurred 5 times within a 2-year period. Neoplasms were discovered during pregnancy in 7 patients; these were characterized by extensive myxoid change, but none of the tumors that occurred during pregnancy showed significant cellular atypism or mitotic activity. Local excision is recommended as initial therapy and also for recurrences.
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Smooth muscle tumors of the vulva.
F. A. Tavassoli, Henry J. Norris · PubMed · 1979 · 213 citations
Estrogen receptor protein in bone and soft tissue tumors.
Stephen Weiss, John Μ. Langloss, B M Shmookler et al. · PubMed · 1986 · 57 citations
Superficial leiomyomas. A clinicopathologic study of 34 cases.
Ryohei Yokoyama, Hiroshi Hashimoto, Yutaka Daimaru et al. · PubMed · 1987 · 45 citations