Concepedia

Publication | Closed Access

RET/PTC oncogene activation is an early event in thyroid carcinogenesis.

250

Citations

0

References

1995

Year

Giuseppe Viglietto, Gennaro Chiappetta, Francisco J. Martínez‐Tello, F Fukunaga, Giovanni Tallini, D. Rigopoulou, Roberta Visconti, Andrea M. Mastro, Massimo Santoro, Alfredo Fusco
PubMed

Abstract

RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.