CD11c ⁺ Dendritic Cells Accelerate the Rejection of Older Cardiac Transplants via Interleukin-17A

Abstract

These results demonstrate a critical role of old donor CD11c+ dendritic cells in mounting age-dependent alloimmune responses with an augmented interleukin-17A response in recipient animals. Targeting interleukin-17A may serve as a novel therapeutic approach when older organs are transplanted.