Predicting oral absorption of drugs: a case study with a novel class of antimicrobial agents.

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms <i>Haemophilus </i><i>i</i><i>nfluenzae</i> and <i>Moraxella </i><i>c</i><i>atarrhalis</i>

Michaël Génin, Debra A. Allwine, David Anderson et al. · Journal of Medicinal Chemistry · 2000 · 726 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

Allen R. Hilgers, Robert A. Conradi, Philip S. Burton · Pharmaceutical Research · 1990 · 582 citations

Pharmacy, Pharmaceutics, Pharmacology +15

Correlation of Gene Expression of Ten Drug Efflux Proteins of the ATP-Binding Cassette Transporter Family in Normal Human Jejunum and in Human Intestinal Epithelial Caco-2 Cell Monolayers

Jan Taipalensuu, Hans Törnblom, Greger Lindberg et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 444 citations

Medicine, Cell Biology, Pharmacology +13