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Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications

Jongwon Lim, Michael D. Altman, James Α. Baker, Jason D. Brubaker, Hongmin Chen, Yiping Chen, Melanie A. Kleinschek, Chaomin Li, Duan Liu, John Maclean,

Bioorganic & Medicinal Chemistry Letters · 2015 · 32 citations · 18 references

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18

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

Jennifer D. Irvine, Lori H. Takahashi, Karen Lockhart et al. · Journal of Pharmaceutical Sciences · 1999 · 976 citations

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan et al. · Nature · 2002 · 849 citations

, , +14

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

Capucine Pïcard, Anne Puel, Marion Bonnet et al. · Science · 2003 · 822 citations

, , +17

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

Shyun Li, Astrid Strelow, Elizabeth J. Fontana et al. · Proceedings of the National Academy of Sciences · 2002 · 686 citations

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Treatment of lupus‐prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

Franck J. Barrat, Thea Meeker, Jean H. Chan et al. · European Journal of Immunology · 2007 · 275 citations · Full text

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