Jean H. Chan

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

Franck J. Barrat, Thea Meeker, Josh Gregorio et al. · The Journal of Experimental Medicine · 2005 · 915 citations · Full text

Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation

Cristiana Guiducci, Gary Ott, Jean H. Chan et al. · The Journal of Experimental Medicine · 2006 · 378 citations · Full text

Adaptive Immune System, Innate Immune System, Immunology +18

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

Cristiana Guiducci, Mei Gong, Zhaohui Xu et al. · Nature · 2010 · 365 citations

Tlr Recognition, Autoimmune Disease, Systemic Lupus Erythematosus Treatment +8

Treatment of lupus‐prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

Franck J. Barrat, Thea Meeker, Jean H. Chan et al. · European Journal of Immunology · 2007 · 273 citations · Full text

Dual Inhibitor, Immunology, Pathology +18

IL-10 regulates plasmacytoid dendritic cell response to CpG-containing immunostimulatory sequences

Omar Duramad, Karen L. Fearon, Jean H. Chan et al. · Blood · 2003 · 135 citations · Full text