Mitochondria Selective <i>S</i> -Nitrosation by Mitochondria-Targeted <i>S</i> -Nitrosothiol Protects Against Post-Infarct Heart Failure in Mouse Hearts

Abstract

MitoSNO action acutely at reperfusion reduces infarct size and protects from post-myocardial infarction heart failure. Therefore, targeted inhibition of mitochondrial complex I in the first minutes of reperfusion by MitoSNO is a rational therapeutic strategy for preventing subsequent heart failure in patients undergoing IR injury.