Transactions of the Royal Society of Tropical Medicine and Hygiene · 1960 · 167 citations · 12 references
MedicineNutritional SciencesPharmacotherapyHuman NutritionIron Metabolism DisordersMicronutrient NutritionAnemiaFolate DeficiencyIron DeficiencyMicronutrient SupplementationVitamin PhysiologyVitamin SupplementationFolate Deficiency TreatmentMaternal Folate DeficiencyMaternal Folate StatusMaternal Vitamin B12 DeficiencyMicronutrient Supplementation In PregnancyPregnancy-associated Vitamin B12 DeficiencyVitamin B12 Deficiency AnemiaVitamin B12 Deficiency Treatment
Patients with severe nutritional and pregnancy megaloblastic anaemia were treated with combinations of folic acid and vitamin B12 in doses ranging from an ineffective to a presumed fully effective level. The study was designed to determine the separate contributions of the two vitamins to the response to treatment of this anaemia and particularly to detect any interaction (potentiation) between the two vitamins. Folic acid was found to give significant variations in response, but vitamin B12 did not show any effect. No interaction was detected.
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An improved method for the rapid estimation of vitamin B12 in serum.
Richard W. Vilter, Daniel L. Horrigan, John F. Mueller et al. · Blood · 1950 · 107 citations · Full text
Interrelationship of Folacin, Vitamin B12 and Choline
Arnold Schaefer, W. D. Salmon, D.R. Strength et al. · Journal of Nutrition · 1950 · 71 citations
The relationship of vitamin B12 and folic acid in megaloblastic anemias.
Nieweg Ho, Faber Jg, de Vries Ja et al. · PubMed · 1954 · 65 citations