Concepedia

Interplay Between CYP3A-Mediated Metabolism and Polarized Efflux of Terfenadine and Its Metabolites in Intestinal Epithelial Caco-2 (TC7) Cell Monolayers

Shamsi Raeissi, Ismael J. Hidalgo, Juan Segura‐Aguilar, Per Artursson

Pharmaceutical Research · 1999 · 68 citations · 23 references

DOI

Concepts

References

23

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

, , +17

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

, , +11

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

Alex Sparreboom, Judith van Asperen, Ulrich Mayer et al. · Proceedings of the National Academy of Sciences · 1997 · 880 citations

, , +15

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

Kenneth S. Lown, Robert R. Mayo, Alan B. Leichtman et al. · Clinical Pharmacology & Therapeutics · 1997 · 682 citations · Full text

, , +17

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

, , +17