Application of the p53 and K-ras gene mutation patterns for cytologic diagnosis of recurrent lung carcinomas

Abstract

The authors successfully detected the same mutations in recurrent cytologic specimens as those in the initially resected tumors by PCR-SSCP analysis. These findings suggest that the p53 and K-ras gene mutation patterns are effective markers for the detection of recurrent lung carcinoma in cytologic specimens. Cancer (Cancer Cytopathol)