Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

A novel vascular endothelial growth factor, VEGF‐C, is a ligand for the Flt4 (VEGFR‐3) and KDR (VEGFR‐2) receptor tyrosine kinases.

Vladimir Joukov, Katri Pajusola, Arja Kaipainen et al. · The EMBO Journal · 1996 · 1.7K citations · Full text

Life Sciences, Cell Biology, Pharmacology +11

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

Laura S. Schmidt, Fuh-Mei Duh, Fan Chen et al. · Nature Genetics · 1997 · 1.5K citations

Medicine, Genetics, Oncology +17

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

Arja Kaipainen, Jaana Korhonen, Tuija Mustonen et al. · Proceedings of the National Academy of Sciences · 1995 · 1.4K citations

Life Sciences, Developmental Biology, Molecular Biology +13

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Michael Jeltsch, Arja Kaipainen, Vladimir Joukov et al. · Science · 1997 · 1.3K citations · Full text

Medicine, Immunology, Oncology +17

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

B Millauer, Laura K. Shawver, Karl H. Plate et al. · Nature · 1994 · 1.2K citations

Medicine, Cancer Biology, Oncology +12