Concepedia

The CKLF1-C19 peptide attenuates allergic lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma

Linhua Tian, W. Li, Jianan Wang, Yi Zhang, Yi Zheng, H. Qi, Xiaohuan Guo, Yi Zhang, Dalong Ma, Hua Shen,

Allergy · 2010 · 33 citations · 39 references

DOI

Abstract

Thus, C19 can attenuate airway eosinophilia and lung inflammation by inhibiting CCR3- and CCR4-mediated chemotaxis in a mouse model of asthma. Given its ability to inhibit human CCR3- and CCR4-meditated chemotaxis, C19 has great therapeutic potential for use in the treatment and control of allergic asthma.

References

39

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Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

James J. Lee, Dawn Dimina, MiMi P. Macias et al. · Science · 2004 · 705 citations

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The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4

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