Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

Enhancement of Antitumor Immunity by CTLA-4 Blockade

Dana R. Leach, Matthew F. Krummel, James P. Allison · Science · 1996 · 3.9K citations

Tumor Immunology, B7 Family, Allergy +15

A Cell Culture Model for T Lymphocyte Clonal Anergy

Ronald H. Schwartz · Science · 1990 · 1.9K citations

T Cell Tolerance, Autoimmune Disease, Allergy +13

A Theory of Self-Nonself Discrimination

Peter A. Bretscher, Melvin Cohn · Science · 1970 · 1.7K citations

Discrimination, Immunology, Immunologic Mechanism +23

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Fiona Harding, James G. McArthur, Jane A. Gross et al. · Nature · 1992 · 1.5K citations

Autoimmune Disease, T-cell Clones, Immunology +10

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Megan Barnden, Jan Allison, William R. Heath · Immunology and Cell Biology · 1998 · 1.5K citations