Heterozygosity for <i>IL23R</i> p.Arg381Gln confers a protective effect not only against Crohn’s disease but also ulcerative colitis

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Jean‐Pierre Hugot, Mathias Chamaillard, Habib Zouali et al. · Nature · 2001 · 5.6K citations

Inflammation, Autoimmune Disease, Immunology +6

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Yasunori Ogura, Denise K. Bonen, Naohiro Inohara et al. · Nature · 2001 · 5K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +8

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.6K citations

Lymphocyte Development, Immune Cell Development, Adaptive Immune System +10

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

Inflammation, Autoimmune Disease, Tissue Inflammation +11

Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

Mark S. Silverberg, Jack Satsangi, Tariq Ahmad et al. · Canadian Journal of Gastroenterology · 2005 · 3.3K citations · Full text