Comparative bioactivation of the novel anti‐tuberculosis agent PA‐824 in<i>Mycobacteria</i>and a subcellular fraction of human liver

Abstract

PA-824 was metabolized by des-nitrification in Ddn and M. tuberculosis, but this does not occur in human liver S9 and M. smegmatis. Thus, PA-824 was selectively bioactivated in M. tuberculosis and there was no evidence for 'cross-activation' by human enzymes.