Insulin inhibition of platelet‐endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance.

Helmut O. Steinberg, H Chaker, R Leaming et al. · Journal of Clinical Investigation · 1996 · 1.7K citations · Full text

Medicine, Endocrinology, Internal Medicine +15

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

Mhairi C. Towler, D. Grahame Hardie · Circulation Research · 2007 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Nitric oxide release accounts for insulin's vascular effects in humans.

Urs Scherrer, D Randin, Péter Vollenweider et al. · Journal of Clinical Investigation · 1994 · 759 citations · Full text

Medicine, Endocrinology, Physiology +15

Roles for Insulin Receptor, PI3-Kinase, and <i>Akt</i> in Insulin-Signaling Pathways Related to Production of Nitric Oxide in Human Vascular Endothelial Cells

Guangyuan Zeng, Frederick H. Nystrom, Lingamanaidu V. Ravichandran et al. · Circulation · 2000 · 742 citations

Life Sciences, Cell Biology, Molecular Biology +13

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

Alison Calver, Joe Collier, Patrick Vallance · Journal of Clinical Investigation · 1992 · 527 citations · Full text

Medicine, Endocrinology, Pharmacology +14