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Studies on synthetic polypeptide antigens. XV. The immunochemical properties of ferrocenyl-poly Glu-58Lys-36Tyr-6 (no. 2) conjugates.
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1966
Year
Bioorganic ChemistryEngineeringImmunochemical PropertiesGlycobiologyImmunologyAntigen ProcessingOrganic ChemistryPolypeptide ChainChemistryLong Half-livesChemical BiologyPolymersFerrocenyl-poly Glu-58lys-36tyr-6Metabolic EngineeringImmunochemistryHuman MetabolismBiochemistrySynthetic Polypeptide AntigensBioconjugationBiomolecular EngineeringShort PolymersNatural SciencesMetabolism
The metallocenes, of which ferrocene is a prototype, have three distinct advantages for use in metabolic studies: they incorporate radioactive heavy metal atoms with relatively long half-lives; they are biologically stable and probably cannot be reutilized by the animal in any significant amount; and they may become electron-dense if short polymers of the metallocenes are attached to the polypeptide chain.