Coagulation factors and the protein C system as determinants of thrombin generation in a normal population

Mutation in blood coagulation factor V associated with resistance to activated protein C

Rogier M. Bertina, Bobby P. C. Koeleman, Ted Koster et al. · Nature · 1994 · 3.8K citations

Medicine, Genetics, Hematology +14

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

Medicine, Cardiology, Pharmacology +16

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

B Osterud, S I Rapaport · Proceedings of the National Academy of Sciences · 1977 · 796 citations · Full text

Medicine, Biochemistry, Hematology +17

Thrombin generation, a function test of the haemostaticthrombotic system

Raed Al Dieri, Erik De Smedt, Suzette Beguı́n et al. · Thrombosis and Haemostasis · 2006 · 463 citations · Full text

Medicine, Hematology, Pharmacology +17

Identification of Patients at Low Risk for Recurrent Venous Thromboembolism by Measuring Thrombin Generation

Gregor Hron, Marietta Kollars, Bernd R. Binder et al. · JAMA · 2006 · 375 citations

Medicine, Hematology, Hemostasis +13