Gene therapy of experimental brain tumors using neural progenitor cells

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Luigi Naldini, Ulrike Blömer, Fred H. Gage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor

Angela Gritti, Lidia Cova, Paola Frolichsthal et al. · Journal of Neuroscience · 1996 · 1K citations · Full text

Life Sciences, Cell Biology, Neuroscience +17

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

Jonathan Flax, S. Aurora, Chunhua Yang et al. · Nature Biotechnology · 1998 · 773 citations

Life Sciences, Cell Biology, Developmental Biology +16

Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

Rosemary A. Fricker, Melissa K. Carpenter, Christian Winkler et al. · Journal of Neuroscience · 1999 · 563 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Isolation and Cloning of Multipotential Stem Cells from the Embryonic Human CNS and Establishment of Transplantable Human Neural Stem Cell Lines by Epigenetic Stimulation

Angelo L. Vescovi, Eugenio Parati, Angela Gritti et al. · Experimental Neurology · 1999 · 560 citations

Life Sciences, Cell Biology, Neuroscience +16