Concepedia

Novel Role for E4 Region Genes in Protection of Adenovirus Vectors from Lysis by Cytotoxic T Lymphocytes

Johanne Kaplan, Donna Armentano, Abraham Scaria, Lisa Woodworth, Sarah E. Pennington, Samuel C. Wadsworth, Alan E. Smith, Richard J. Gregory

Journal of Virology · 1999 · 25 citations · 23 references

DOIFull text

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Concepts

Abstract

Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.

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