The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells

Ann E. Tollefson, Abraham Scaria, Terry Hermiston, +3

Journal of Virology

Viral ReplicationViral PathogenesisImmunologyCell DeathPathology +14

CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10

Guo-Xiang Ruan, Elizabeth Barry, Dan Yu, +3

Molecular Therapy

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

Darlene Barr, Julie Tubb, Deron Ferguson, +4

PubMed

The E3-11.6-kDa Adenovirus Death Protein (ADP) Is Required for Efficient Cell Death: Characterization of Cells Infected withadpMutants

Ann E. Tollefson, Jan S. Ryerse, Abraham Scaria, +2

Virology

ApoptosisViral PathogenesisImmunologyCell DeathVirology +6

Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial

Jeffrey S. Heier, Saleema Kherani, Shilpa J. Desai, +13

The Lancet

Open-label TrialTranslational MedicineOcular DiseaseOphthalmologyExperimental Ophthalmology +6

Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

Timothy K. MacLachlan, Michael Lukason, Margaret E. Collins, +11

Molecular Therapy

Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

Brenda Burnham, Shelley Nass, Elton Kong, +7

Human Gene Therapy Methods

Viral ReplicationEngineeringSynthetic VirologyMolecular BiologyAnalytical Ultracentrifugation +15

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

Shelley Nass, Maryellen Mattingly, Denise Woodcock, +7

Molecular Therapy — Methods & Clinical Development

Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization

Peter Pecháň, Hillard Rubin, Michael Lukason, +5

Gene Therapy

Ocular DiseaseAngiogenesisOphthalmologyRetinal NeovascularizationVascular Biology +5

The 11,600-MW protein encoded by region E3 of adenovirus is expressed early but is greatly amplified at late stages of infection

Ann E. Tollefson, Abraham Scaria, S K Saha, +1

Journal of Virology

Virus Structure11,600-Mw ProteinRegion E3Molecular VirologyNeurovirology +13