IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Alberto Pugliese, Markus Zeller, Alarico Fernandez et al. · Nature Genetics · 1997 · 947 citations

Life Sciences, Genetics, Molecular Genetics +8

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

Petros Vafiadis, Simon T. Bennett, John A. Todd et al. · Nature Genetics · 1997 · 816 citations

Life Sciences, Endocrinology, Genetics +13

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

S. T. Bennett, Anneke Lucassen, Stephen Gough et al. · Nature Genetics · 1995 · 754 citations

Medicine, Genetics, Molecular Genetics +10

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

Graeme I. Bell, Shiro Horita, John H. Karam · Diabetes · 1984 · 744 citations

Life Sciences, Genetics, Molecular Genetics +10

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

Anette‐Gabriele Ziegler, Michael Hummel, M Schenker et al. · Diabetes · 1999 · 639 citations

Life Sciences, Endocrinology, Pediatrics +17