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Oxygen Plus Pressure Plus Time: The Etiology of Bronchopulmonary Dysplasia
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1975
Year
Oxygen Plus PressureAdvanced Lung DiseaseRespiratory Distress Syndrome (Pulmonary Critical Care)MedicinePhysiologyPediatricsPediatric Lung DiseasePulmonary PhysiologyPositive-pressure VentilationLung MechanicsRespiratory Distress Syndrome (Neonatal Medicine)Pulmonary MedicineRespiration (Physiology)Chronic Pulmonary SyndromePulmonary DiseaseOxygen ConcentrationsNeonatal Pulmonary Physiology
Ten infants developed the chronic pulmonary syndrome designated bronchopulmonary dysplasia, following artificial (assisted) ventilation using a volume-regulated positive-pressure respirator. Despite previous reports implicating elevated oxygen concentrations for prolonged periods of time, only two infants required more than 80% oxygen for more than 24 hours, and only one infant required 60% oxygen for more than 100 hours. "Immature" lungs when exposed to inspired oxygen concentrations over 40% for as little as three days via positive-pressure ventilation may develop bronchopulmonary dysplasia. The role of the underlying disease and the relationship with Wilson-Mikity syndrome remain uncertain.