Isolation of Novel Lignans, Heteroclitins F and G, from the Stems of Kadsura heteroclita, and Anti-lipid Peroxidative Actions of Heteroclitins A-G and Related Compounds in the in Vitro Rat Liver Homogenate System.

Abstract

From the stems of Kadsura heteroclita, two new lignans named heteroclitins F and G were isolated and their structures were determined by various spectroscopic means including an X-ray diffraction method. Dibenzocyclooctadiene type lignans and related compounds isolated from the stems of K. heteroclita, potently inhibited the lipid peroxidation in the rat liver homogenate stimulated by Fe(2+)-ascorbic acid, CCl4-reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and adenosine 5'-diphosphate-NADPH.