Ocular Manifestations of Ariboflavinosis

Abstract

This paper presents observations on ocular changes in a small group of patients known to be receiving insufficient riboflavin, and on the beneficial effects of riboflavin therapy on these lesions. From slitlamp examination and ocular signs the principal manifestation was found to be a keratitis. The corneal lesions improved or disappeared upon riboflavin therapy, and recurred on cessation of it. Two cases of keratitis associated with syphilis but resistant to antisyphilitic treatment were studied without attempting to control the diet. Riboflavin therapy appeared to be distinctly beneficial in these cases.