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THE PATHOLOGIC ANATOMY OF THE LIVER IN EXOPHTHALMIC GOITER

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1933

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Article1 December 1933THE PATHOLOGIC ANATOMY OF THE LIVER IN EXOPHTHALMIC GOITERDONALD C. BEAVER, M.D., JOHN DEJ. PEMBERTON, M.D.DONALD C. BEAVER, M.D., JOHN DEJ. PEMBERTON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-687 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years icterus has been known as a complication in cases of severe exophthalmic goiter. It has not been demonstrated, however, until fairly recently, that the liver may frequently undergo severe functional and anatomic changes in the syndrome of exophthalmic goiter.Habershon,1in 1874, reported a fatal case of exophthalmic goiter in which jaundice was a complicating feature. Sutcliff,2in 1898, observed jaundice in an extraordinarily acute case of exophthalmic goiter. Eder,3in 1906, reported three cases of exophthalmic goiter, in each of which jaundice was observed. He commented that Dieulafoy,4in 1901, had described the association of jaundice...Bibliography1. HABERSHON SO: Exophthalmic goiter; heart disease; jaundice; death, Lancet, 1874, i, 510. CrossrefGoogle Scholar2. SUTCLIFF EH: An extraordinarily acute case of Graves' disease, Lancet, 1898, i, 717. CrossrefGoogle Scholar3. EDER MD: Three cases of jaundice occurring in persons suffering from exophthalmic goiter, Lancet, 1906, i, 1758. CrossrefGoogle Scholar4. DIEULAFOY G: Quoted by Eder. Google Scholar5. CHVOSTEK F: Morbus Basedowi und die Hyperthyreosen, 1917, Julius Springer, Berlin. CrossrefGoogle Scholar6. BOOTHBY WM: Part 4. Diagnosis and treatment of the diseases of the thyroid gland, 1922, Oxford Medicine, Oxford University Press, New York, iii. Google Scholar7. CROTTI A: Thyroid and thymus, 1922, Lea and Febiger, Philadelphia. Google Scholar8. ASSMANN H: Leber und Milz bei Morbus Basedow, München. med. Wchnschr., 1931, lxxviii, 221-225. Google Scholar9. FARRANT R: Hyperthyroidism: its experimental production in animals, Brit. Med. Jr., 1913, ii, 1363-1367. Google Scholar10. KURIYAMA S: The influence of thyroid feeding upon carbohydrate metabolism. I. The storage and mobilization of the liver glycogen in thyroid-fed animals, Jr. Biol. Chem., 1918, xxxiii, 193-205. CrossrefGoogle Scholar11. CRAMERKRAUSE WRA: Carbohydrate metabolism in its relation to the thyroid gland; the effect of thyroid feeding on the glycogen content of the liver and on the nitrogen distribution in the urine, Proc. Roy. Soc. London, Series B, 1913, lxxxvi, 550-560. Google Scholar12. HASHIMOTO H: Heart in experimental hyperthyroidism with special reference to its histology, Endocrinology, 1921, v, 579-606. CrossrefGoogle Scholar13. SIMONDSBRANDES JPWW: Effect of experimental hyperthyroidism and of inanition on heart, liver and kidneys, Arch. Path., 1930, ix, 445-460. Google Scholar14. YOUMANSWARFIELD JBLM: Liver injury in thyrotoxicosis as evidenced by decreased functional efficiency, Arch. Int. Med., 1926, xxxvii, 1-17. CrossrefGoogle Scholar15. HEILMEYER L: Blutfarbstoffwechselstudien. 3. Mitteilung: Blutmauserung und Leberfunktion beim Morbus Basedow, Deutsch. Arch. f. klin. Med., 1931, clxxi, 515-528. Google Scholar16. ASKANAZY M: Pathologisch-anatomische Beiträge zur Kenntnis des Morbus Basedowii, insbesondere über die dabei auftretende Muskelerkrankung, Deutsch. Arch. f. klin. Med., 1898, lxi, 118-186. Google Scholar17. MARINELENHART DCH: Pathological anatomy of exophthalmic goiter: the anatomical and physiological relation of the thyroid gland to the disease; the treatment, Arch. Int. Med., 1911, viii, 265-316. CrossrefGoogle Scholar18. PETTAVEL CA: Beitrag zur pathologischen Anatomie des Morbus Basedowii, Deutsch. Ztschr. f. Chir., 1912, cxvi, 488-543. CrossrefGoogle Scholar19. MATTI H: Quoted by Chvostek. Google Scholar20. MCCARRISON R: The thyroid gland in health and disease, 1918, Wm. Wood and Company, New York. Google Scholar21. KERRRUSK WJGY: Acute yellow atrophy associated with hyperthyroidism, Med. Clin. N. Am., 1922, vi, 445-459. Google Scholar22. RAABTERPLAN WC: Morbus Basedowii mit subakuter Leberatrophie, Med. Klin., 1923, xix, 1154-1156. Google Scholar23. BARKER LF: Thyreo-intoxication with necrosis and atrophy of liver, damage to heart muscle and kidneys, and terminal bronchopneumonia, Med. Clin. N. Am., 1930, xiv, 261-263. Google Scholar24. WELLER CV: Hepatic lesions associated with exophthalmic goiter, Trans. Assoc. Am. Phys., 1930, xlv, 71-76. Google Scholar25. KERR WJ: Necrosis of heart and liver in thyrotoxicosis, with some notes on possible changes in other organs, Northwest Med., 1930, xxix, 430-431. Google Scholar26. LEWIS W: Hyperthyroidism and associated pathology, Am. Jr. Med. Sci., 1931, clxxxi, 65-74. CrossrefGoogle Scholar27. PLUMMER HS: Part 2. The function of the thyroid gland, In: MAYO, C. H., and PLUMMER, H. S.: The thyroid gland; The Beaumont Foundation Lectures, Series 4, 1926, C. V. Mosby Company, St. Louis. Google Scholar28. JACKSON CM: In: MORRIS' human anatomy, 1914, P. Blakiston's Son and Company, Philadelphia. Google Scholar29. GRAY H: Anatomy, descriptive and surgical, 1908, Lea and Febiger, Philadelphia. Google Scholar30. VIERORDT KH: Anatomische, physiologische, und physikalische Daten und Tabellen, 1906, G. Fischer, Jena. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication August 27, 1932.From the Section on Pathologic Anatomy and the Section on Surgery, The Mayo Clinic. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyrotoxicosis associated with severe hypoalbuminemia and hyperbilirubinemiaHistological Changes in Autoimmune Hepatitis with Graves' Disease: A Child Case ReportOTHER SYSTEMS IN THYROTOXICOSISExacerbation of erythropoietic protoporphyria by hyperthyroidismA case of severe cholestatic jaundice with hyperthyroidism successfully treated with methimazoleSevere Cholestatic Jaundice in Hyperthyroidism after Treatment with 131-IodineThe liver in other (nondiabetic) endocrine disordersHypertransaminasemia in Two Children with HyperthyroidismAbnormal Results of Liver Function Tests in Patients with Graves' DiseaseThyroid Storm Presenting With Liver FailureReduction of thyroxine-induced necrotic foci and thrombi in the mouse liver by androgen, oestrogen and glucocorticoid but not by progesteroneLiver changes in patients with hyperthyroidismCholestatic jaundice in hyperthyroidismEthanol, Thyroid Hormones and Acute Liver Injury: Is There a Relationship?Quantitative histochemical resolution of the oxidation-reduction and phosphate potentials within the simple hepatic acinus.Gut-thyroid interrelationshipsPrevention and management of hyperthyroid stormROLE OF THE SODIUM PUMP IN THE REGULATION OF LIVER METABOLISM IN EXPERIMENTAL ALCOHOLISMThe effect of altered thyroid function on the ultrastructure of the human liverIntroduction—a perspectiveEnergy storageRelative importance of different tissues in the synthesis of fatty acidsComparative anatomy of adipose tissue 1Adipose tissue in migratory birdsMetabolic pathways in the insect fat body 1Fat metabolism in fishThe physiological role of brown adipose tissue 1The development of adipose tissueHistogenesis 1The fine structure of adipose tissuesMorphology of adipose tissue: a microscopic anatomy of fatPathological anatomy of adipose tissue 1Lipid components of adipose tissueFatty substances containing ether linkagesFatty acid patterns in human adipose tissueStructural sugars in adipose tissueDistribution of adrenergic nerve fibers in brown and white adipose tissueStructural aspects of adipose tissue: A summary attempting to synthesize the information contained in the preceding chaptersFatty acid synthesis in adipose tissueTriglyceride metabolismEnzymes involved in carbohydrate metabolism in adipose tissueGlyceride biosynthesis, glyceride breakdown and glycogen breakdown in adipose tissue: mechanisms and regulationPathways of glucose metabolismPathways of glucose metabolism IIFructose metabolism in adipose tissue from normal and diabetic rats 1The clearing factor lipase activity of adipose tissueAdipose tissue lipases IIHormone‐sensitive lipolytic activity of adipose tissue 1Glycogen metabolism in adipose tissueAdipose tissue in diabetesRegulation of fatty acid release with particular reference to pituitary factorsRelease of free fatty acids from adipose tissue in vitro in relation to rates of triglyceride synthesis and degradationLipid peroxidation 1Net gas exchange and oxygen consumptionConversion of amino acids to fatty acidsAmino acid and protein metabolism 1Regulation of fatty acid esterification in adipose tissue incubated in vitroEffect of feeding on fatty acid synthesis 1Effects of aging on the composition and metabolism of adipose tissue in the ratEffect of biologically active peptides on adipose tissueComparative physiology of adipose tissue in different sites and in different speciesSelective labeling of adipose tissue in vivoPerfusion of isolated adipose tissue: FFA release and blood flow in rat parametrial fat bodyMetabolism of human adipose tissue in vitroThe metabolism of isolated fat cellsMetabolism of isolated adipose tissue: a summaryChylomicron metabolism: uptake and metabolism by perfused adipose tissue 1Metabolism of lipids in chylomicrons and very low‐density lipoproteinsParticulate lipid components in plasmaEffect of dietary and endocrine factors on adipose tissue growth 1The pituitary gland and the mobilization of fatThe adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology 1In vivo and in vitro adipokinetic effects of corticotropin and related peptides 1Lipid‐mobilizing activity during fastingInhibition of lipid mobilizationAutonomic nervous system and adipose tissueAutonomic nervous system and adipose tissueAction of lipomobilizing hormones on adipose tissuePsychogenic effects on lipid mobilizationAdipositySome physiological and clinical implications of lipid mobilization from adipose tissue 1Metabolism of adipose tissue in experimental obesityThe measurement of human adipose tissue massLipid composition and metabolism of subcutaneous adipose tissue and lipoma of manLipodystrophyEffect of adipose tissue extracts on the insulin activity of human serumBibliographyJaundice and thyrotoxicosis in the absence of congestive heart failureEffect of Thyroxine, Thiouracil and Ambient Temperature on the Utilization of Vitamin a by Vitamin A-deficient RatsThyrotoxic confusional state: A report of four casesEye Signs in Hepatic CirrhosisChemistry and Physiology of the Thyroid-stimulating HormoneDie SchilddrüseHyperthyroidismKrankheiten der SchilddrüsePostoperative Thyroid StormAcute Liver Disease: Its Causes and TreatmentThe Pathogenesis of Atrophy of the Left Lobe of the Liver of ManPost-Necrotic (toxic) cirrhosis: Its clinical significanceSevere Hypoprothrombinemia Following Propylthiouracil Treatment of ThyrotoxicosisHypoprothrombinemia in HyperthyroidismThyroidectomy using local anesthesiaThe Chemistry and Physiology of the Thyroid HormoneSome Observations on Thiouracil Neutropenia, with Special Reference to the Sternal MarrowThyroid crisisThe importance of latent hepatic diseaseMorbus BasedowInnere SekretionThe Treatment of Pre-Eclampsia**Read, by invitation, at a meeting of the Brooklyn Gynecological Society, as part of a program on Maternal Mortality, May 3, 1940.Die thyreotoxische Krise, das thyreotoxische ComaThe acutely III jaundiced Patient: a report of twenty-one instances of hepatic icterus, seven of whom had high blood nitrogenLive function in hepatic and extrahepatic diseases 1 December 1933Volume 7, Issue 6Page: 687-708KeywordsLiverSurgery ePublished: 1 December 2008 Issue Published: 1 December 1933 PDF downloadLoading ...

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